Nuclear power plants require water cooling, and avoid climate change. Climate change reduces the volume and increases the ambient temperature of cooling water flows. Nuclear capacity may be taken offline, implying an expensive restart at best.
This is probably not a first order problem with nuclear power specifically, but it is illustrative of how when you start pushing systems out of their accustomed range you start seeing informal assumptions violated by the real world.
Large cooling systems need to account for uncertain water supplies and increasing water temperatures.